PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

AIMS:Protein kinase Cα (PKCα) is one of the predominant PKC isoforms that phosphorylate cardiac troponin. PKCα is implicated in heart failure and serves as a potential therapeutic target, however, the exact consequences for contractile function in human myocardium are unclear. This study aimed to in...

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Bibliographic Details
Main Authors: Viola Kooij, Pingbo Zhang, Sander R Piersma, Vasco Sequeira, Nicky M Boontje, Paul J M Wijnker, Connie R Jiménez, Kornelia E Jaquet, Cris dos Remedios, Anne M Murphy, Jennifer E Van Eyk, Jolanda van der Velden, Ger Jm Stienen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792062?pdf=render

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http://europepmc.org/articles/PMC3792062?pdf=render

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