An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection

An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection

The CD8+ T cell response to the intracellular parasite Toxoplasma gondii varies dramatically between mouse strains, resulting in stark differences in control of the parasite. Protection in BALB/c mice can be attributed to an unusually strong and protective MHC-1 Ld-restricted CD8+ T cell response di...

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Bibliographic Details
Main Authors: Alexandra Tsitsiklis, Derek J. Bangs, Lydia K. Lutes, Shiao W. Chan, Kristina M. Geiger, Andrew J. Modzelewski, Lara Labarta-Bajo, Yang Wang, Elina I. Zuniga, Shaodong Dai, Ellen A. Robey
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cells
MHC
Toxoplasma gondii
exhaustion
chronic infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01464/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01464/full

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