Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells

Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells

KLF5 (Krüppel-like factor 5) plays critical roles in normal and cancer cell proliferation through modulating cell cycle progression. In this study, we demonstrated that curcumin targeted KLF5 by promoting its proteasome degradation, but not by inhibiting its transcription in bladder cancer cells. W...

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Bibliographic Details
Main Authors: Yang Gao, Qi Shi, Shan Xu, Chong Du, Liang Liang, Kaijie Wu, Ke Wang, Xinyang Wang, Luke S. Chang, Dalin He, Peng Guo
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
KLF5
curcumin
bladder cancer
protein degradation
YAP
TAZ
Online Access:http://www.mdpi.com/1422-0067/15/9/15173

Internet

http://www.mdpi.com/1422-0067/15/9/15173

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