LC-MS/MS Analysis and Pharmacokinetics of Sodium (±)-5-Bromo-2-(α-hydroxypentyl) Benzoate (BZP), an Innovative Potent Anti-Ischemic Stroke Agent in Rats

LC-MS/MS Analysis and Pharmacokinetics of Sodium (±)-5-Bromo-2-(α-hydroxypentyl) Benzoate (BZP), an Innovative Potent Anti-Ischemic Stroke Agent in Rats

A rapid, sensitive and selective liquid chromatography-triple quadrupole mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of sodium (±)-5-Bromo-2-(α-hydroxypentyl) benzoate (BZP) and its active metabolite 3-butyl-6-bromo-1(3H)-isobenzofuranone (Br-NB...

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Bibliographic Details
Main Authors: Xin Tian, Bingjie Liu, Yuhai Zhang, Hongmeng Li, Jingyao Wei, Gaoju Wang, Junbiao Chang, Hailing Qiao
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
BZP
metabolite
Br-NBP
LC-MS/MS
pharmacokinetics
rat plasma
Online Access:http://www.mdpi.com/1420-3049/21/4/501

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http://www.mdpi.com/1420-3049/21/4/501

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