Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice.

Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous system. It regulates several biological processes such as...

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Main Authors: Erick Contreras-Vallejos, Elías Utreras, Daniel A Bórquez, Michaela Prochazkova, Anita Terse, Howard Jaffe, Andrea Toledo, Cristina Arruti, Harish C Pant, Ashok B Kulkarni, Christian González-Billault
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3962345?pdf=render