Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease

Amyloid β (Aβ) accumulation is considered the main culprit in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that decreasing Aβ production at very early stages of AD could be a promising strategy to slow down disease progression. Serotonin 5-HT4 receptor activation stimula...

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Bibliographic Details
Main Authors: Patrizia eGiannoni, Florence eGaven, Dimitri eDe Bundel, Kevin eBaranger, Evelyne eMarchetti-Gauthier, François S Roman, Emmanuel eValjent, Philippe eMarin, Joël eBockaert, Santiago eRivera, Sylvie eClaeysen
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
Serotonin
amyloid plaques
G protein-coupled receptor
Alpha-secretase
sAPP alpha
preventive pharmacotherapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00096/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00096/full

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