Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?

Inflammation, characterized by high numbers of infiltrating leukocytes and a high HLA Class I expression, is associated with a bad prognosis in uveal melanoma (UM). We wondered whether mutations in <i>GNA11</i> or <i>GNAQ</i> differentially affect inflammation and HLA express...

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Bibliographic Details
Main Authors: Christiaan van Weeghel, Annemijn P. A. Wierenga, Mieke Versluis, Thorbald van Hall, Pieter A. van der Velden, Wilma G. M. Kroes, Ulrich Pfeffer, Gregorius P. M. Luyten, Martine J. Jager
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
uveal melanoma
mutations
chromosome aberrations
mRNA expression
survival
Online Access:https://www.mdpi.com/2072-6694/11/8/1127

Internet

https://www.mdpi.com/2072-6694/11/8/1127

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