Endothelin-1 is over-expressed in amyotrophic lateral sclerosis and induces motor neuron cell death

Endothelin-1 is over-expressed in amyotrophic lateral sclerosis and induces motor neuron cell death

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss of motor neurons (MNs) and astrogliosis. Recent evidence suggests that factors secreted by activated astrocytes might contribute to degeneration of MNs. We focused on endothelin-1 (ET-1), a peptide...

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Bibliographic Details
Main Authors: Eugenia Ranno, Simona D'Antoni, Michela Spatuzza, Antonio Berretta, Floriana Laureanti, Carmela M. Bonaccorso, Rosalia Pellitteri, Patrizia Longone, Alida Spalloni, Anand M. Iyer, Eleonora Aronica, Maria Vincenza Catania
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Motor neuron
Astrocyte
Endothelin
Reactive gliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000096

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http://www.sciencedirect.com/science/article/pii/S0969996114000096

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