Lipophilic ester and amide derivatives of rosmarinic acid protect cells against H2O2-induced DNA damage and apoptosis: The potential role of intracellular accumulation and labile iron chelation

Lipophilic ester and amide derivatives of rosmarinic acid protect cells against H2O2-induced DNA damage and apoptosis: The potential role of intracellular accumulation and labile iron chelation

Phenolic acids represent abundant components contained in human diet. However, the negative charge in their carboxylic group limits their capacity to diffuse through biological membranes, thus hindering their access to cell interior. In order to promote the diffusion of rosmarinic acid through biolo...

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Bibliographic Details
Main Authors: Paraskevi S. Gerogianni, Maria V. Chatziathanasiadou, Dimitrios A. Diamantis, Andreas G. Tzakos, Dimitrios Galaris
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
Cell apoptosis
DNA damage
Labile iron
Oxidative stress
Rosmarinic acid derivatives
Cell uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718300260

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http://www.sciencedirect.com/science/article/pii/S2213231718300260

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