Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features

Components of the pre-messenger RNA splicing machinery are frequently mutated in myeloid malignancies. Mutations in <i>LUC7L2, PRPF8,</i> <i>SF3B1</i>, <i>SRSF2</i>, <i>U2AF1</i>, and <i>ZRSR2</i> genes occur at various frequencies ranging...

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Bibliographic Details
Main Authors: Valeria Visconte, Megan O. Nakashima, Heesun J. Rogers
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
aml
mds
Online Access:https://www.mdpi.com/2072-6694/11/12/1844