Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma

Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. Dysregulation of HomeoboxD10 (HOXD10) was found to suppress or promote cancer progression in different cancer types. The function and regulation of HOXD10 r...

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Bibliographic Details
Main Authors: Yulin Guo, Yaojun Peng, Dan Gao, Meiying Zhang, Weili Yang, Enqiang Linghu, James G. Herman, François Fuks, Guanglong Dong, Mingzhou Guo
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Clinical Epigenetics
Subjects:
HOXD10
DNA methylation
Hepatocellular carcinoma
IGFBP3
ERK1/2
Online Access:http://link.springer.com/article/10.1186/s13148-017-0412-9

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http://link.springer.com/article/10.1186/s13148-017-0412-9

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