Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

RNA-binding protein hnRNP A2/B1 is suggested to promote miRNA processing as a m6A 'reader'. Here, the authors determine crystal structures of RRM domains of hnRNP A2/B1 in complex with various RNA substrates and determine that hnRNP A2/B1 may function as an auxiliary factor in 'm6A sw...

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Bibliographic Details
Main Authors: Baixing Wu, Shichen Su, Deepak P. Patil, Hehua Liu, Jianhua Gan, Samie R. Jaffrey, Jinbiao Ma
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02770-z

Internet

https://doi.org/10.1038/s41467-017-02770-z

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