Conventional and Regulatory CD4+ T Cells That Share Identical TCRs Are Derived from Common Clones.

Results from studies comparing the diversity and specificity of the TCR repertoires expressed by conventional (Tconv) and regulatory (Treg) CD4+ T cell have varied depending on the experimental system employed. We developed a new model in which T cells express a single fixed TCRα chain, randomly rea...

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Bibliographic Details
Main Authors: Kyle J Wolf, Ryan O Emerson, Jeanette Pingel, R Mark Buller, Richard J DiPaolo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4839724?pdf=render