Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates

Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates

Despite decades of clinical trials for diffuse intrinsic pontine glioma (DIPG), patient survival does not exceed 10% at two years post-diagnosis. Lack of benefit from systemic chemotherapy may be attributed to an intact bloodbrain barrier (BBB). We aim to develop a theoretical model including releva...

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Bibliographic Details
Main Authors: Fatma E. El-Khouly, Dannis G. van Vuurden, Thom Stroink, Esther Hulleman, Gertjan J. L. Kaspers, N. Harry Hendrikse, Sophie E. M. Veldhuijzen van Zanten
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Oncology
Subjects:
diffuse intrinsic pontine glioma
blood–brain barrier
chemotherapy
convection-enhanced delivery
drug delivery
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00254/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2017.00254/full

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