Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.

Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.

Expulsion of parasitic gastrointestinal nematodes requires diverse effector mechanisms coordinated by a Th2-type response. The evolutionarily conserved JmjC protein; Myc Induced Nuclear Antigen (Mina) has been shown to repress IL4, a key Th2 cytokine, suggesting Mina may negatively regulate nematode...

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Bibliographic Details
Main Authors: Meenu R Pillai, Belgacem Mihi, Kenji Ishiwata, Kiminori Nakamura, Naoya Sakuragi, David B Finkelstein, Maureen A McGargill, Toshinori Nakayama, Tokiyoshi Ayabe, Mathew L Coleman, Mark Bix
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211244

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https://doi.org/10.1371/journal.pone.0211244

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