Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties

Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties

Pyrazino[2,1-a]isoquinolin analogues were reported as potent activators of Nrf2/ARE signaling both in vitro and in vivo by our group. In this study, we simplified the ring system to investigate the functions of various parts of the pyrazino[2,1-a]isoquinolin scaffold. We proved that the tetrahydrois...

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Bibliographic Details
Main Authors: Hongbin Dai, Qiong Jiao, Tian Liu, Qidong You, Zhengyu Jiang
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
Nrf2 activator
pyrido[1,2-a]pyrazin analogues
oxidative stress
physicochemical properties
Online Access:https://www.mdpi.com/1420-3049/22/9/1541

Internet

https://www.mdpi.com/1420-3049/22/9/1541

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