Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?

Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?

Protein tyrosine phosphatases (PTPs), of the receptor and non-receptor classes, are key signaling molecules that play critical roles in cellular regulation underlying diverse physiological events. Aberrant signaling as a result of genetic mutation or altered expression levels has been associated wit...

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Bibliographic Details
Main Authors: Yotis A. Senis, Alastair J. Barr
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
tyrosine phosphatase
receptor
phosphorylation
ectodomain
biotherapeutic
biological
inhibitor
disease
Online Access:http://www.mdpi.com/1420-3049/23/3/569

Internet

http://www.mdpi.com/1420-3049/23/3/569

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