Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

Abstract Background The Tumor Microenviroment (TME) is a complex milieu that is increasingly recognized as a key factor in multiple stages of disease progression and responses to therapy as well as escape from immune surveillance. However, the precise contribution of specific immune effector and imm...

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Bibliographic Details
Main Authors: Massimo Granai, Lucia Mundo, Ayse U. Akarca, Maria Chiara Siciliano, Hasan Rizvi, Virginia Mancini, Noel Onyango, Joshua Nyagol, Nicholas Othieno Abinya, Ibrahim Maha, Sandra Margielewska, Wenbin Wi, Michele Bibas, Pier Paolo Piccaluga, Leticia Quintanilla-Martinez, Falko Fend, Stefano Lazzi, Lorenzo Leoncini, Teresa Marafioti
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Infectious Agents and Cancer
Subjects:
Burkitt lymphoma
Tumour microenvironment
EBV
PD-L1
Immunotherapy
Immune checkpoint
Online Access:http://link.springer.com/article/10.1186/s13027-020-00292-w

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http://link.springer.com/article/10.1186/s13027-020-00292-w

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