Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency

Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency

Abstract Background Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal recessive disorder characterized by neonatal hyperammonemia, elevated c...

Full description

Bibliographic Details
Main Authors: Maria Beatriz Herrera Sanchez, Sara Previdi, Stefania Bruno, Valentina Fonsato, Maria Chiara Deregibus, Sharad Kholia, Sara Petrillo, Emanuela Tolosano, Rossana Critelli, Marco Spada, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta, Giovanni Camussi
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Stem Cell Research & Therapy
Subjects:
Liver transplantation
Citrullinemia type I
Stem cells
Extracellular vesicles
Online Access:http://link.springer.com/article/10.1186/s13287-017-0628-9

Internet

http://link.springer.com/article/10.1186/s13287-017-0628-9

Similar Items