Transcriptional Inhibition of Matrix Metal loproteinase 9 (MMP-9) Activity by a c-fos/Estrogen Receptor Fusion Protein is Mediated by the Proximal AP-1 Site of the MMP-9 Promoter and Correlates with Reduced Tumor Cell Invasion

Transcriptional Inhibition of Matrix Metal loproteinase 9 (MMP-9) Activity by a c-fos/Estrogen Receptor Fusion Protein is Mediated by the Proximal AP-1 Site of the MMP-9 Promoter and Correlates with Reduced Tumor Cell Invasion

Tumor cell invasion of basement membranes is one of the hallmarks of malignant transformation. Tumor cells secrete proteolytic enzymes known as matrix metalloproteinases (MMPs) which degrade extracellular matrix molecules. Increased expression of MMP-9 has been associated with acquisition of invasi...

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Bibliographic Details
Main Authors: David L. Crowe, Tamara N. Brown
Format: Article
Language:English
Published: Elsevier 1999-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
invasion
matrix metalloproteinase
transcription factor
AP-1
extracellular matrix
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800281

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http://www.sciencedirect.com/science/article/pii/S1476558699800281

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