Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist

Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist

Abstract Background Gastrin Releasing Peptide receptor (GRPr)-based radioligands have shown great promise for diagnostic imaging of GRPr-positive cancers, such as prostate and breast. The present study aims at developing and evaluating a versatile GRPr-based probe for both PET/SPECT imaging as well...

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Bibliographic Details
Main Authors: Michael Hofstetter, Euy Sung Moon, Fabio D’Angelo, Lucien Geissbühler, Ian Alberts, Ali Afshar-Oromieh, Frank Rösch, Axel Rominger, Eleni Gourni
Format: Article
Language:English
Published: SpringerOpen 2020-11-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Gastrin releasing peptide receptor (GRPr)
AAZTA
Prostate cancer
Imaging
Peptide radionuclide therapy
Online Access:https://doi.org/10.1186/s41181-020-00115-8

Internet

https://doi.org/10.1186/s41181-020-00115-8

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