β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation

β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The accumulation of abnormal aggregates of different proteins is a common feature in...

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Bibliographic Details
Main Authors: Cristina Pinto, Danilo B. Medinas, Francisco Fuentes-Villalobos, Jaime Maripillán, Ariel F. Castro, Agustín D. Martínez, Nelson Osses, Claudio Hetz, Juan P. Henríquez
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
β-Catenin
Accumulation
ALS
Motor neuron
GSK3β inhibition
Differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301524

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http://www.sciencedirect.com/science/article/pii/S0969996119301524

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