Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein

Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein

Autoimmune diseases are caused by uncontrolled endogenous immune responses against healthy cells. They may develop due to an impaired function of regulatory T cells (Tregs), which normally suppress self-specific effector immune cells. Interleukin 2 (IL-2) and tumor necrosis factor (TNF) have been id...

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Bibliographic Details
Main Authors: Tanja Padutsch, Maksim Sendetski, Carina Huber, Nathalie Peters, Klaus Pfizenmaier, John R. Bethea, Roland E. Kontermann, Roman Fischer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
Tregs
cytokine fusion proteins
autoimmune disease
inflammation
TNFR2
TNF
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01490/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01490/full

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