The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells

The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells

Abstract Background Dietary fiber is effective for colorectal cancer (CRC) treatment. Interleukin-6 (IL-6) and its adaptors are potential targets for CRC therapy. Butyrate, a metabolite of dietary fiber, is a new, highly safe type of targeted drug. Methods In this study, Cell Counting Kit-8 cell via...

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Bibliographic Details
Main Authors: Yin Yuan, Bo Li, Yanbin Kuang, Shuo Ni, Aoxiang Zhuge, Jing Yang, Longxian Lv, Silan Gu, Ren Yan, Yating Li, Kaicen Wang, Liya Yang, Xueling Zhu, Jingjing Wu, Xiaoyuan Bian, Lanjuan Li
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Sodium butyrate
GP130
TRAF5
Protein stability
Online Access:http://link.springer.com/article/10.1186/s12935-020-01305-9

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http://link.springer.com/article/10.1186/s12935-020-01305-9

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