Mutational Analysis of the Binding of Alternative Substrates and Inhibitors to the Active Site of Human Glutathione Transferase Pl−1

Mutational Analysis of the Binding of Alternative Substrates and Inhibitors to the Active Site of Human Glutathione Transferase Pl−1

Glutathione transferases (GSTs) are enzymes that play a critical role in cellular detoxication by catalyzing the nucleophilic attack of glutathione on the electrophilic center of a number of xenobiotic compounds, including many therapeutic drugs. Mutations of amino acid residues in the glutathione-b...

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Bibliographic Details
Main Authors: Abeer Shokeer, Aram Ismail, Usama M. Hegazy, Rüdiger H. Kolm, Bengt Mannervik
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Processes
Subjects:
Glutathione transferase P1–1
Telintra
Telcyta
alternative thiol substrates
inhibitor binding energy
Online Access:https://www.mdpi.com/2227-9717/8/10/1232

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https://www.mdpi.com/2227-9717/8/10/1232

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