Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine

Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine

BackgroundGlioblastoma (GBM) is the most common primary malignant brain tumor in adults. Ubiquitously expressed volume-regulated anion channels (VRAC) are thought to play a role in cell proliferation, migration, and apoptosis. VRAC are heteromeric channel complexes assembled from proteins belonging...

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Bibliographic Details
Main Authors: Sebastian Rubino, Martin D. Bach, Alexandra L. Schober, Ian H. Lambert, Alexander A. Mongin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
leucine-rich repeat-containing 8A
volume-regulated anion channel
temozolomide
carmustine
cisplatin
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2018.00142/full

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http://journal.frontiersin.org/article/10.3389/fonc.2018.00142/full

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