Semi-Automatic Synthesis, Antiproliferative Activity and DNA-Binding Properties of New Netropsin and bis-Netropsin Analogues

Semi-Automatic Synthesis, Antiproliferative Activity and DNA-Binding Properties of New Netropsin and bis-Netropsin Analogues

A general route for the semi-automatic synthesis of some new potential minor groove binders was established. Six four-numbered sub-libraries of new netropsin and bis-netropsin analogues have been synthesized using a Syncore Reactor. The structures of the all new substances prepared in this investig...

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Bibliographic Details
Main Authors: Jakub Szerszenowicz, Danuta Drozdowska
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
combinatorial chemistry
solid phase synthesis
netropsin analogue
non-intercalative DNA binding agent
DNA minor groove binder
Online Access:http://www.mdpi.com/1420-3049/19/8/11300

Internet

http://www.mdpi.com/1420-3049/19/8/11300

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