Bioreversible Derivatives of Phenol. 1. The Role of Human Serum Albumin as Related to the Stability and Binding Properties of Carbonate Esters with Fatty Acid-like Structures in Aqueous Solution and Biological Media

Bioreversible Derivatives of Phenol. 1. The Role of Human Serum Albumin as Related to the Stability and Binding Properties of Carbonate Esters with Fatty Acid-like Structures in Aqueous Solution and Biological Media

With the overall objective of assessing the potential of utilizing plasma protein binding interactions in combination with the prodrug approach for improving the pharmacokinetics of drug substances, a series of model carbonate ester prodrugs of phenol, encompassing derivatives with fatty acid-like s...

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Bibliographic Details
Main Authors: Claus Larsen, Jesper Ostergaard
Format: Article
Language:English
Published: MDPI AG 2007-10-01
Series:Molecules
Subjects:
bioreversible derivatives
carbonate ester
esterase-like properties
human serum albumin
prodrug
plasma protein binding
Online Access:http://www.mdpi.com/1420-3049/12/10/2380/

Internet

http://www.mdpi.com/1420-3049/12/10/2380/

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