The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury

The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury

Abstract Background The endogenously produced gaseous molecule carbon monoxide is able to promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon monoxide releasing molecules (CORM) regarding inflammation in neuronal tissues has not been studied in detail. In this in...

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Bibliographic Details
Main Authors: Felix Ulbrich, Claus Hagmann, Hartmut Buerkle, Carlos C. Romao, Nils Schallner, Ulrich Goebel, Julia Biermann
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neuroinflammation
Subjects:
Ischemia/reperfusion injury
Carbon monoxide
Neuro-inflammation
Neuroprotection
sGC-ß1
Heat shock proteins
Online Access:http://link.springer.com/article/10.1186/s12974-017-0905-7

Internet

http://link.springer.com/article/10.1186/s12974-017-0905-7

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