c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway

c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway

Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. However, how PCSK9 mediates LDLR degradation is still unknown. By combining a shotgun proteomic method and differential an...

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Bibliographic Details
Main Authors: David Hornby, Lizhi Liu, Weiming Xu
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Molecules
Subjects:
c-IAP1
PCSK9
TNF-α
LDLR
Cholesterol
K27
ubiquitination
E3 ligase
Stub1
Online Access:http://www.mdpi.com/1420-3049/17/10/12086

Internet

http://www.mdpi.com/1420-3049/17/10/12086

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