Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL-6 and TNF-α

Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL-6 and TNF-α

Abstract Background This study aimed to explore whether the mechanical stretching-induced expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in pulmonary veins occurred through the stretch-activated channel (SAC)/ mitogen-activated protein kinases (MAPKs) pathway. Methods Sixty m...

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Bibliographic Details
Main Authors: Wenhui Huang, Hongjin Liu, Yichao Pan, Hongwei Yang, Jing Lin, Hui Zhang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Pulmonary hypertension due to left heart disease
Pulmonary vein
MAPKs
IL-6
TNF-α
Online Access:https://doi.org/10.1186/s13019-021-01471-5

Internet

https://doi.org/10.1186/s13019-021-01471-5

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