Anti-cancer Effects of a Chemically Modified miR-143 on Bladder Cancer by Either Systemic or Intravesical Treatment

Anti-cancer Effects of a Chemically Modified miR-143 on Bladder Cancer by Either Systemic or Intravesical Treatment

We developed a novel chemically modified miR-143 (miR-143#12), and with it we investigated the contribution of miR-143 to the pathogenesis of bladder cancer (BC), in which miR-143 is extremely downregulated. Since miR-143 silenced K-RAS and RAS effector-signaling molecules Erk and Akt, we performed...

Full description

Bibliographic Details
Main Authors: Yuki Yoshikawa, Kohei Taniguchi, Takuya Tsujino, Kazuki Heishima, Teruo Inamoto, Tomoaki Takai, Koichiro Minami, Haruhito Azuma, Kanjiro Miyata, Kotaro Hayashi, Kazunori Kataoka, Yukihiro Akao
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119300221

Internet

http://www.sciencedirect.com/science/article/pii/S2329050119300221

Similar Items