Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer.

Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer.

In the present study, we have taken the novel approach of using an in vitro model representative of tamoxifen-withdrawal subsequent to clinical relapse to achieve a greater understanding of the mechanisms that serve to maintain the resistant-cell phenotype, independent of any agonistic impact of tam...

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Bibliographic Details
Main Authors: Andrew Stone, Fatima Valdés-Mora, Julia M W Gee, Lynne Farrow, Richard A McClelland, Heidi Fiegl, Carol Dutkowski, Rachael A McCloy, Robert L Sutherland, Elizabeth A Musgrove, Robert I Nicholson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3393679?pdf=render

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http://europepmc.org/articles/PMC3393679?pdf=render

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