PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1

PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1

Doxorubicin (DOX), a chemotherapeutic drug widely used in the clinical setting, is known to cause serious cardiotoxicity and greatly reduces the survival rate as well as quality of life of patients receiving chemotherapy. Peroxisome proliferation activated receptor α (PPARα) is a type of ligand acti...

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Bibliographic Details
Main Authors: Wei Wang, Qin Fang, Zhihao Zhang, Daowen Wang, Lujin Wu, Yan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
PPARα
mitochondria
apoptosis
cardiotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.528267/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.528267/full

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