The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2

The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2

Summary Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central to this event is increased gene transcription. Small Rho-GTPases not only control the actin cytoskeleton, but are also implicated in gene regulation. How...

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Bibliographic Details
Main Authors: Jos Van Rijssel, Ilse Timmerman, Floris P. J. Van Alphen, Mark Hoogenboezem, Olexandr Korchynskyi, Dirk Geerts, Judy Geissler, Kris A. Reedquist, Hans W. M. Niessen, Jaap D. Van Buul
Format: Article
Language:English
Published: The Company of Biologists 2013-04-01
Series:Biology Open
Subjects:
Endothelium
GEF
GTPase
Inflammation
Signal transduction
Online Access:http://bio.biologists.org/content/2/6/569

Internet

http://bio.biologists.org/content/2/6/569

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