Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect

Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect

Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAII and aquaporin-1 are expressed in the thin descending limb (...

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Bibliographic Details
Main Authors: Devishree Krishnan, Wanling Pan, Megan R. Beggs, Francesco Trepiccione, Régine Chambrey, Dominique Eladari, Emmanuelle Cordat, Henrik Dimke, R. Todd Alexander
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Physiology
Subjects:
carbonic anhydrase II
polyuria
urine concentration
aquaporin-1
metabolic
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01108/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.01108/full

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