PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

Osteoarthritis (OA) is one of the most common types of arthritis in the elderly people. It has been known that chondrocyte apoptosis occurs in OA cartilage; however, the detailed molecular mechanism remains unclear. In the current study, we aimed to elucidate the role of double-stranded RNA-dependen...

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Bibliographic Details
Main Authors: Ching-Hou Ma, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hsia Hung, Wan-Ching Chou, Yun-Ching Chang, Pei-Ling Hsieh, Kun-Ling Tsai
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antioxidants
Subjects:
osteoarthritis
chondrocyte
PKR
oxidative stress
mitochondrial dysfunction
Online Access:https://www.mdpi.com/2076-3921/8/9/370

Internet

https://www.mdpi.com/2076-3921/8/9/370

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