Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors

Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors

The usefulness of non-steroidal anti-inflammatory drugs (NSAIDs) is hampered by their gastrointestinal side effects. Non-selective cyclooxygenases inhibitors interfere with both COX-1 and COX-2 isozymes. Since COX-1 mediates cytoprotection of gastric mucosa, its inhibition leads to the undesirable s...

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Bibliographic Details
Main Authors: Mohamed G. Badrey, Hassan M. Abdel-Aziz, Sobhi M. Gomha, Mohamed M. Abdalla, Abdelrahman S. Mayhoub
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
aminopyrazolopyridine
anti-inflammatory
cyclooxygenase
hydrazonyl halides
selective inhibitors
Online Access:http://www.mdpi.com/1420-3049/20/8/15287

Internet

http://www.mdpi.com/1420-3049/20/8/15287

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