Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.

Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.

Soluble forms of oligomeric beta-amyloid (Aβ) are thought to play a central role in Alzheimer's disease (AD). Transgenic manipulation of methylation of the serine/threonine protein phosphatase, PP2A, was recently shown to alter the sensitivity of mice to AD-related impairments resulting from ac...

Full description

Bibliographic Details
Main Authors: Kesava Asam, Agnieszka Staniszewski, Hong Zhang, Scott L Melideo, Adolfo Mazzeo, Michael Voronkov, Kristen L Huber, Eduardo Pérez, Maxwell Stock, Jeffry B Stock, Ottavio Arancio, Russell E Nicholls
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5734769?pdf=render

Internet

http://europepmc.org/articles/PMC5734769?pdf=render

Similar Items