The clinical significance of serum SCC-Ag combined with CD105 in patients with cervical cancer during the early stage diagnosis

• Main Authors: Ru-Chan Ma, Hong Bi, Sen-Yang Cao
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-09-01
• Series: Journal of Hainan Medical University
• Subjects: and 52 cases uterine fibroids patients were selected as normal cervical group; serum samples were collected in the early morning fasting condition; SCC-Ag and CD105 were checked by ELISA method; SCC-Ag and CD105 of two groups were analyzed by t-test; and to compare SCC-Ag and CD105 in different TMN staging; lymph gland metastasis and non-lymph gland metastasis in patients with cervical cancer; the correlation analysis was used by Pearson correlation analysis method. Results: These results came from ELISA method; comparing with normal cervical group; the SCC-Ag and CD105 of cervical cancer group increased; the difference was statistically significant. Comparing with Ⅰ period of TMN staging; SCC-Ag and CD105 of Ⅱ period increased; Ⅲ; Ⅳ period increased; the difference was statistically significant. Comparing with Ⅱ period; SCC-Ag and CD105 of Ⅲ; the difference was statistically significant. Comparing with non-lymph gland metastasis; SCC-Ag and CD105 of lymph gland metastasis increased in cervical cancer with surgical treatment; the difference was statistically significant. According to Pearson correlation analysis; SCC-Ag and CD105 were positively correlated. Conclusion: SCC-Ag and CD105 in patients with cervical cancer increase highly; it has important clinical value that of serum SCCAg combined with CD105 in the early diagnosis of cervical cancer; especially it has clinical guiding significance to staging and lymph gland metastasis of cervical cancer; SCC-Ag; CD105; Cervical cancer; Early stage diagnosis; Clinical significance
• Online Access: http://www.hnykdxxb.com/PDF/201618/26.pdf

Objective: To invest the clinical significance of serum SCC-Ag combined with CD105 in early diagnosis of cervical cancer to provide new ideas for early diagnosis and clinical treatment of cervical cancer. Methods: A total of 74 cases cervical cancer patients were selected as cervical cancer group, and 52 cases uterine fibroids patients were selected as normal cervical group, serum samples were collected in the early morning fasting condition, SCC-Ag and CD105 were checked by ELISA method, SCC-Ag and CD105 of two groups were analyzed by t-test, and to compare SCC-Ag and CD105 in different TMN staging, lymph gland metastasis and non-lymph gland metastasis in patients with cervical cancer, the correlation analysis was used by Pearson correlation analysis method. Results: These results came from ELISA method, comparing with normal cervical group, the SCC-Ag and CD105 of cervical cancer group increased, the difference was statistically significant. Comparing with Ⅰ period of TMN staging, SCC-Ag and CD105 of Ⅱ period increased, Ⅲ, Ⅳ period increased, the difference was statistically significant. Comparing with Ⅱ period, SCC-Ag and CD105 of Ⅲ, Ⅳ period increased, the difference was statistically significant. Comparing with non-lymph gland metastasis, SCC-Ag and CD105 of lymph gland metastasis increased in cervical cancer with surgical treatment, the difference was statistically significant. According to Pearson correlation analysis, SCC-Ag and CD105 were positively correlated. Conclusion: SCC-Ag and CD105 in patients with cervical cancer increase highly, it has important clinical value that of serum SCCAg combined with CD105 in the early diagnosis of cervical cancer, especially it has clinical guiding significance to staging and lymph gland metastasis of cervical cancer, and it is worthy of clinical reference.