SUMOylation and deacetylation affect NF-κB p65 activity induced by high glucose in human lens epithelial cells

AIM: To explore the effects of IκBα SUMOylation and NF-κB p65 deacetylation on NF-κB p65 activity induced by high glucose in cultured human lens epithelial cells (HLECs). METHODS: HLECs (SRA01/04) were cultured with 5.5, 25, and 50 mmol/L glucose media for 24h, and with 50 mmol/L glucose media for...

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Bibliographic Details
Main Authors: Xiao Han, Xiao-Xuan Dong, Ming-Yu Shi, Li Feng, Xin-Ling Wang, Jin-Song Zhang, Qi-Chang Yan
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2019-09-01
Series:International Journal of Ophthalmology
Subjects:
Online Access:http://www.ijo.cn/en_publish/2019/9/20190901.pdf