Downmodulation of El A Protein Expression as a Novel Strategy to Design Cancer-Selective Adenoviruses

Downmodulation of El A Protein Expression as a Novel Strategy to Design Cancer-Selective Adenoviruses

Oncolytic adenoviruses are being tested as potential therapies for human malignant tumors, including gliomas. Here we report for the first time that a mutation in the E1A gene results in low levels of ElA protein, conditioning the replication of mutant adenoviruses specifically to cancer cells. In...

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Bibliographic Details
Main Authors: Hong Jiang, Ramon Alemany, Candelaria Gomez-Manzano, Diana R. Medrano, Michael G. Lemoine, Melissa V. Olson, Marta M. Alonso, Ok-Hee Lee, Charles C. Conrad, W.K. Alfred Yung, Juan Fueyo
Format: Article
Language:English
Published: Elsevier 2005-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
glioma
oncolytic
adenovirus
E1A
CR1
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605801046

Internet

http://www.sciencedirect.com/science/article/pii/S1476558605801046

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