The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders

Prion diseases are fatal and transmissible neurodegenerative diseases in which the cellular form of the prion protein ‘PrP<sup>c</sup>’, misfolds into an infectious and aggregation prone isoform termed PrP<sup>Sc</sup>, which is the primary component of prions. Many neurodege...

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Bibliographic Details
Main Authors: Pearl Cherry, Sabine Gilch
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/19/7016