Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial

Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial

Abstract Background Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely prescribed phosphodiesterase-5 inhibitor that increases blood flow in other...

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Bibliographic Details
Main Authors: Mathilde M. H. Pauls, Natasha Clarke, Sarah Trippier, Shai Betteridge, Franklyn A. Howe, Usman Khan, Christina Kruuse, Jeremy B. Madigan, Barry Moynihan, Anthony C. Pereira, Debbie Rolfe, Egill Rostrup, Caroline E. Haig, Thomas R. Barrick, Jeremy D. Isaacs, Atticus H. Hainsworth
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Trials
Subjects:
Tadalafil
Cerebral blood flow
Vascular cognitive impairment
Vascular dementia
Phosphodiesterase
MRI
Online Access:http://link.springer.com/article/10.1186/s13063-017-1973-9

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http://link.springer.com/article/10.1186/s13063-017-1973-9

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