Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes
Abstract APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral prote...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-09-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://link.springer.com/article/10.1186/s12981-017-0173-8 |