HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes

HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes

X-adrenoleukodystrophy (X-ALD) is a peroxisomal metabolic disorder caused by mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). The consistent metabolic abnormality in all forms of X-ALD is an inherited defect in the peroxisomal β-oxidation of v...

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Bibliographic Details
Main Authors: Jaspreet Singh, Mushfiquddin Khan, Inderjit Singh
Format: Article
Language:English
Published: Elsevier 2011-11-01
Series:Journal of Lipid Research
Subjects:
peroxisome
very long chain FA
glia
nitric oxide
cytokine
suberoylanilide hydroxamic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350951

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http://www.sciencedirect.com/science/article/pii/S0022227520350951

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