The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

Endoplasmic reticulum (ER)-associated degradation (ERAD) is a principal mechanism that targets ER-associated proteins for cytosolic proteasomal degradation. Here, our data demonstrate a critical role for the Sel1L-Hrd1 complex, the most conserved branch of ERAD, in early B cell development. Loss of...

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Bibliographic Details
Main Authors: Yewei Ji, Hana Kim, Liu Yang, Haibo Sha, Christopher A. Roman, Qiaoming Long, Ling Qi
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
endoplasmic reticulum-associated degradation
Sel1L
Hrd1
B cell development
pre-B cell receptor
large pre-B cells
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631035X

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http://www.sciencedirect.com/science/article/pii/S221112471631035X

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