Prostate cancer characteristics associated with response to pre-receptor targeting of the androgen axis.

Prostate cancer characteristics associated with response to pre-receptor targeting of the androgen axis.

Factors influencing differential responses of prostate tumors to androgen receptor (AR) axis-directed therapeutics are poorly understood, and predictors of treatment efficacy are needed. We hypothesized that the efficacy of inhibiting DHT ligand synthesis would associate with intra-tumoral androgen...

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Bibliographic Details
Main Authors: Elahe A Mostaghel, Andrew Morgan, Xiaotun Zhang, Brett T Marck, Jing Xia, Rachel Hunter-Merrill, Roman Gulati, Stephen Plymate, Robert L Vessella, Eva Corey, Celestia S Higano, Alvin M Matsumoto, R Bruce Montgomery, Peter S Nelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4214744?pdf=render

Internet

http://europepmc.org/articles/PMC4214744?pdf=render

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