Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration

Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration

Abstract Background Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness. Sphingolipids play a role in glycaemic balance and insulin resistance. Endoplasmic reticulum (ER) stres...

Full description

Bibliographic Details
Main Authors: Katrina Weston-Green, Ilijana Babic, Michael de Santis, Bo Pan, Magdalene K. Montgomery, Todd Mitchell, Xu-Feng Huang, Jessica Nealon
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Biomedical Science
Subjects:
Antipsychotic
Sphingolipid
Ceramide
Sphingomyelin
ER stress
Hyperglycemia
Online Access:http://link.springer.com/article/10.1186/s12929-018-0437-1

Internet

http://link.springer.com/article/10.1186/s12929-018-0437-1

Similar Items