Ketamine's schizophrenia-like effects are prevented by targeting PTP1B

Ketamine's schizophrenia-like effects are prevented by targeting PTP1B

Subanesthetic doses of ketamine induce schizophrenia-like behaviors in mice including hyperlocomotion and deficits in working memory and sensorimotor gating. Here, we examined the effect of in vivo ketamine administration on neuronal properties and endocannabinoid (eCB)-dependent modulation of synap...

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Bibliographic Details
Main Authors: Zhaohong Qin, Li Zhang, Michael A. Zasloff, Alexandre F.R. Stewart, Hsiao-Huei Chen
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
NMDA receptor antagonism
Mice, behavior
Whole cell patch-clamp electrophysiology
Schizophrenia
Endocannabinoid
Trodusquemine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001467

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121001467

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